Ibanga Lemithi le-Medium-Chain Triglycerides (MCT) | I-Lipophilic Solvent kanye ne-Drug Carrier yomlomo/ye-Topical/ejovwayo | USP/EP/ChP

I-Medium-Chain Triglycerides (MCT) yethu iyisithako semithi esihlanzekile kakhulu esakhiwe yi-triglycerides yama-acid anamafutha e-caprylic (C8) agcwele (C8) kanye ne-capric (C10), atholakala kumafutha kakhukhunathi kanye ne-palm kernel.Kubonakala sengathi iwuketshezi olunamafutha olucacile, olungenambala kuya koluphuzi kancane, olune-viscosity ephansi, olunephunga elingathathi hlangothi kanye nokunambithekaI-MCT isebenza njengesithako esihle kakhulu semithi ebulala ama-lipophilic, isithwali semithi sokuthuthukisa ukutholakala kwe-bioavailability, isiqeda ukuvuvukala kwezakhi zokwenziwa, kanye nesithuthukisi sokugeleza kokufakwa kwesikhumba.Inikeza ukuzinza okuphezulu kwe-oxidative, ukumuncwa okusheshayo (ukugeleza kwe-portal ngqo ngaphandle kosawoti we-bile), kanye nokuhambisana okuhle kakhulu nama-API nezinye izinto ezisizayo. Ivumelana ne-USP-NF, EP, JP, kanye ne-ChP pharmacopoeias nge-CDE registration F20220000316. Ifanelekela izixazululo/ama-capsule omlomo, ukhilimu/amafutha asetshenziswayo, ukudla okunomsoco okuphathelene nokuzala, kanye nezinhlelo zokulethwa kwemithi ezizixubayo (i-SEDDS).

Xhumana nathi

Imininingwane Yomkhiqizo

Ama-Triglycerides e-Pharmaceutical Grade Medium-Chain (MCT)

Ukubuka Konke Komkhiqizo

I-Medium-Chain Triglycerides (MCT) iyisithako esisekelwe kahle semithi esiqukethe ingxube yama-triglycerides ama-fatty acid agcwele, ikakhulukazi i-caprylic acid (C8H16O2, i-octanoic acid) kanye ne-capric acid (C10H20O2, i-decanoic acid)Lawa ma-triglyceride atholakala ku-oyili oqinile okhishwe engxenyeni eqinile, eyomile ye-endosperm yekakhukhunathi (iCocos nucifera L.) noma ku-endosperm eyomile ye-oil palm (i-Elaeis guineensis Jacq.)Ama-fatty acid ahlukaniswa namafutha bese ephinda ahlanganiswe ne-glycerol ukuze kukhiqizwe umkhiqizo wokugcina..

Ubunikazi Bomkhiqizo:

Igama Lekhemikhali:Ama-Triglyceride Aphakathi Nesikhathi Esimaphakathi / I-Caprylic/I-Capric Triglyceride
Inombolo ye-CAS:73398-61-5 (futhi 85409-09-2 noma 538-24-9)
Inombolo Yokubhalisa ye-CDE:F20220000316
Ukuthobela Imithetho Ye-Pharmacopoeia:I-ChP (CP2020), i-USP-NF (ama-Triglycerides e-Medium-Chain), i-EP (ama-Triglycerides, i-Medium-Chain), i-JP (ama-triglyceride e-fatty acid e-medium chain)
Amagama afanayo:Uwoyela we-MCT, i-Caprylic/Capric Triglyceride, i-Glycerides i-decanoyl exubile ne-octanoyl, i-Miglyol® 812 elinganayo, i-Labrafac™ CC elinganayo
Ukubukeka:Uketshezi olunamafutha olungenambala kuya koluphuzi kancane, cishe alunaphunga futhi alunambitheki
Indawo Yokuqandisa:Cishe u-0°C

Izici Eziyinhloko Nezinzuzo

1. Izici Ze-Solvent Eziphakeme

Isinyibilikisi esihle kakhulu semithi ye-lipophilic kanye nama-API angancibiliki emanzini kahle
Kuthuthukisa ukuncibilika kanye nokuzinza kwama-lipophilic compounds
Kuthuthukisa ukutholakala kwemithi yeSigaba II kanye neSigaba IV (ukuhlukaniswa kwe-BCS)

2. Ukumuncwa Okusheshayo kanye Nokusetshenziswa Kwemetabolism

Imuncwa ngqo ekujikelezeni kwegazi kwe-portal ngaphandle kwesidingo sama-bile salts noma ama-enzyme e-pancreatic
Kusheshiswa ukugaywa ukuze kunikezwe amandla ngokushesha
Ukulethwa okusheshayo kwe-API ekujikelezeni kwesistimu, okungenzeka kuthuthukise ukuqala kokusebenza

3. Iphrofayili Yokuzinza Ehle Kakhulu

Ukumelana okuphezulu ne-oxidation (inani le-iodine ≤1.0)
Ukuthambekela okuphansi kokucindezeleka kokushisa nokungcoliswa kwe-oxidative
Igcina ukuzinza kanye nokuphila isikhathi eside kwemithi esetshenziswayo
Izinzile emazingeni okushisa ahlukahlukene okugcina (kunconywa ukuthi kube ngu-≤25°C)

4. Izakhiwo Eziphakeme Zomzimba

Ukujiya:~30 mPa·s ku-20°C (i-viscosity ephansi ukuze kube lula ukuyiphatha)
Amandla adonsela phansi aqondile:0.93-0.96 ku-20°C
Inkomba Yokubukeza:1.440-1.452 ku-20°C
I-viscosity ephansi efanelekile kumafomu omthamo oketshezi kanye nowokuqina okuncane

5. Ukuhambisana Okuhle Kakhulu

Iyahambisana nohlu olubanzi lwama-API kanye nezinto ezisizayo zemithi
Ingafakwa kalula ekwakhiweni okuhlukahlukene ngaphandle kwezinkinga zokuhambisana
Iphunga elingathathi hlangothi kanye nokunambitheka - kulungele ukusetshenziswa komuthi lapho ukunambitha kubalulekile khona

6. Iphrofayili Yokulawula Nokuphepha

Isimo se-GRAS (Ngokuvamile Siqashelwa Njengesiphephile)
Akunabuthi, akucasuli isikhumba namehlo
LD50 (igundane, ngomlomo): 29.6 g/kg – kuphephile kakhulu
I-GMP ekhiqizwe ngokulawulwa kwekhwalithi okuqinile
I-CDE ibhalisiwe (F20220000316) emakethe yaseShayina
Kutholakala ngokusekelwa okusemthethweni kokufakwa kwamafayela emhlabeni jikelele