I-Croscarmellose Sodium Superdisintegrant yamaphilisi emithi | Ukuvuvukala okusheshayo, izinga lokusetshenziswa eliphansi 0.5-5% | Ihambisana ne-USP/EP/JP

I-Croscarmellose Sodium yethu iyi-superdisintegrant ehlanzekile kakhulu eyenzelwe izinhlobo zomthamo oqinile womlomo ohlanganisa amaphilisi, ama-capsule, kanye nama-granules. Iyi-sodium carboxymethylcellulose exhunywe ngaphakathi engancibiliki emanzini kodwa ikhula ngokushesha ibe yivolumu yayo yokuqala izikhathi ezingu-4-8 uma ithinta imithombo yamanzi.Lesi sakhiwo esiyingqayizivele esinemicu sinikeza amandla amahle kakhulu okudonsa amanzi kanye nokusebenza kwe-capillary, okuholela ekuqhekekeni kwamaphilisi okuhle kakhulu kanye nokuncibilika kwemithi okuthuthukisiwe.. Ivumelana ne-USP-NF, EP, JP, kanye ne-ChP pharmacopoeias nge-CDE registration F20209990136Izinga lokusetshenziswa elijwayelekile: 0.5-5.0% w/w (2% yokucindezela okuqondile, 3% yokuhlanganisa okumanzi). Kufanelekela ukucindezelwa okuqondile, ukugoba okumanzi (ngaphakathi noma ngaphandle kwe-granular), ukucindezelwa kwe-roller, kanye nokwakheka kwe-capsule

Xhumana nathi

Imininingwane Yomkhiqizo

I-Croscarmellose Sodium Yebanga Lemithi (i-CCS)

Ukubuka Konke Komkhiqizo

I-Crosscarmellose Sodium iyi-sodium carboxymethylcellulose ehlanganiswe ngaphakathi, eyenzelwe ngqo ukusetshenziswa njenge-superdisintegrant ekwakhiweni kwemithi.Ngokungafani neziqhumane ezivamile, inikeza izakhiwo ezihlukile zokuqhumaneka ngamanani aphansi, iqinisekisa ukuqhekeka kwamaphilisi ngokushesha kanye nokuqedwa kwemithi okuthuthukisiwe ukuze kube nokutholakala okungcono kwe-bioavailability..

Ubunikazi Bomkhiqizo:

Igama Lekhemikhali:I-Crosscarmellose Sodium
Inombolo ye-CAS:74811-65-7
Inombolo Yokubhalisa ye-CDE:F20209990136
Ukuthobela Imithetho Ye-Pharmacopoeia:I-ChP, i-USP-NF, i-EP, i-JP, i-BP
Inombolo ye-EC:629-739-2
Amagama afanayo:I-Carboxymethylcellulose exhumene ne-Crosscarmellose, i-E468

Izici Eziyinhloko Nezinzuzo

1. Indlela Ephakeme Yokuqhekeka

Ukuqhekeka kwezenzo ezimbili:Ihlanganisa isenzo se-capillary (ukuhlikihla) nokuvuvukala okusheshayo
Ikhuphukela ku-Ivolumu yayo yokuqala iphindwe ka-4-8lapho uthintana namanzi
Isakhiwo esinezintambo sinikeza amakhono amahle kakhulu okumunca amanzi
Kwakha ukunwetshwa kwemishini okuphula amaphilisi ngokushesha

2. Izinga Lokusebenzisa Eliphansi – Ukusebenza Kahle Kakhulu

Isebenza kahle ekugxilweni okuphansi njenge0.5-5.0% w/w
Ukusetshenziswa okuvamile: 2% kokucindezelwa okuqondile, 3% kokumanzisa
Isixazululo esingabizi kakhulu sokuthuthukiswa kokwakheka

3. Ukuguquguquka Kwesakhiwo

Ifanele zonke izinqubo zokufaka amaphilisi: ukucindezela okuqondile, i-granulation emanzi, ukuhlanganiswa kwama-roller
Ku-granulation emanzi, ingasetshenziswa ngaphakathi kwe-granularly, extra-granularly, noma ihlukaniswe phakathi kwezigaba zombili
Iyahambisana nezindlela zokwakheka kwe-capsule (ukusetshenziswa okungu-10-25%)

4. Izakhiwo Ezinhle Kakhulu Zomzimba

Ukubukeka:Okumhlophe kuya kokumhlophe, impuphu egeleza ngokukhululeka
Izinga Lokufaka Esikhundleni:0.60 – 0.85
Ivolumu Yokuxazulula:10.0 – 30.0 ml
isixazululo se-pH (1%):5.0 – 7.0
Ukulahlekelwa Kokomisa:≤10.0%
Izinsalela Ekushiseni:14.0% – 28.0%
Izinto Ezincibilikayo Zamanzi:≤10.0%
Izinsimbi Ezisindayo:≤10 ppm

5. Ukuhambisana kwe-API kanye nokuzinza

Ingabeakuqukethe ama-peroxide- kuqinisekisa ukuzinza okungcono kwama-API azwela ukubola
Akukho mthelela omubi ekuqineni kwethebhulethi noma ekuqineni kwayo
Ukusebenza kokuhlakazeka kuhlala kufana ngokuhamba kwesikhathi
Akuyona i-GMO, ayinayo i-allergen