I-Carboxymethylcellulose Calcium (CMC-Ca) Superdisintegrant | Amandla Okuvuvukala Okuphezulu Okuqhekeka Kwethebhulethi Okusheshayo | I-USP/EP/ChP Compliant

I-Carboxymethylcellulose Calcium yethu (i-Carmellose Calcium, i-CMC-Ca) iyisithako semithi esihlanzekile kakhulu esisebenza njengesihlanzi, isihlanganisi, kanye nesihlanzi esisebenzayo samafomu omthamo oqinile womlomo.. Usawoti we-calcium we-carboxymethylcellulose, obonakala njengempuphu emhlophe kuya kwemhlophe enganyibiliki emanzini kodwa ekhula ngokushesha ibe yivolumu yayo yokuqala ephindwe kaningana uma ithintana nemithombo yamanzi.. Le ndlela yokuvuvukala eyingqayizivele iqinisekisa ukuqhekeka kwamaphilisi ngokushesha kanye nokuqedwa kwemithi okuthuthukisiwe. Izinzuzo ezibalulekile zifaka: ukungabikho kokuqukethwe kwe-sodium (okufanele iziguli ezinezifo zenhliziyo nezinomkhawulo we-sodium), ukucindezelwa okuhle kakhulu, kanye nokuhambisana nezinqubo zokucindezelwa okuqondile kanye nezinqubo zokumanzisa . Ivumelana ne-USP-NF, EP, JP, kanye ne-ChP pharmacopoeias ene-CDE registration F20230000328. Izinga lokusetshenziswa elijwayelekile: 0.5-15% w/w.

Xhumana nathi

Imininingwane Yomkhiqizo

Ibanga Lemithi I-Carboxymethylcellulose Calcium (i-Carmellose Calcium, i-CMC-Ca)

Ukubuka Konke Komkhiqizo

I-Carboxymethylcellulose I-Calcium iyi-calcium salt ye-polycarboxymethyl ether ye-cellulose. Kuyisithako semithi esisebenza ngezindlela eziningi esisetshenziswa kabanzi njengesithako esiqhekekile, esihlanganisayo, nesixubayo ezinhlotsheni zomthamo oqinile womlomo ohlanganisa amaphilisi nama-capsule Ngokungafani nomlingani wayo we-sodium, usawoti we-calcium unikeza inzuzo yokwakheka okungenasodium, okwenza kube kuhle kakhulu kubantu abanezinkinga zenhliziyo kanye ne-sodium..

Ubunikazi Bomkhiqizo:

Igama Lekhemikhali:I-Carboxymethylcellulose I-Calcium / I-Carmelose I-Calcium
Inombolo ye-CAS:9050-04-8
Inombolo Yokubhalisa ye-CDE:F20230000328
Ukuthobela Imithetho Ye-Pharmacopoeia:I-ChP, i-USP-NF, i-EP, i-JP
Amagama afanayo:I-calcium carboxymethylcellulose, i-calcium CMC, i-CMC-Ca, i-carmelose Calcium
ABANYE:I-UTY7PDF93L
Ukubukeka:Impuphu emhlophe kuya kophuzi-mhlophe noma engemhlophe nhlobo, ethambile ngemva kokomiswa
Ukuncibilika:Ayincibiliki emanzini, i-acetone, utshwala, kanye ne-toluene; iyavuvukala emanzini ukuze yakhe i-suspension

Izici Eziyinhloko Nezinzuzo

1. Indlela Ephakeme Yokuqhekeka

Ayincibiliki emanzini kodwa ivuvukala ngokushesha iye ku-izikhathi eziningana ivolumu yayo yokuqalalapho uthintana nemithombo yamanzi
Kudala ingcindezi yomshini ephula amaphilisi ngokushesha
Iqinisekisa ukuhlakazeka okusheshayo nokuphelele ukuze kuthuthukiswe ukuhlakazeka kwezidakamizwa
Isebenza kahle ngisho nasemaphilisini aqinile lapho ezinye izinto eziqhekekile zingase zingasebenzi kahle

2. Isithasiselo Esinemisebenzi Eminingi

Ukungavumelani:Umsebenzi oyinhloko njenge-tablet disintegrant kumazinga angu-0.5-15%
Isibophezeli:Isibopho esisebenzayo ezinqubweni ze-granulation ezimanzi
Isixubi/Isigcwalisi:Ingasebenza njengesihlanzi sethebhulethi
Usizo Lokumiswa:Isetshenziswa njengesiqinisi sokumiswa ekulungiseleleni ngomlomo nangaphandle

3. Inzuzo Engenayo I-Sodium

Ayiqukethe i-sodium - ilungele iziguli ezinezinkinga zenhliziyo nemithambo yegazi kanye neziguli ezivinjelwe i-sodium
Ibhekana nezidingo ezikhulayo zokulawula kanye neziguli zezinhlobo ze-sodium ephansi
Ihlangabezana nezitayela zokuqamba ezihlanzekile nezinakekela impilo

4. Ukuhambisana okuhle kakhulu kwe-API

Isebenza kahle kakhulu ku-imithi ye-cephalosporin, ngezimpawu zokuthuthukisa ukuqhekeka ezibonisiwe
Isakhiwo esihle se-chelating sizuzisa amakilasi athile e-API
Iyahambisana nezithako eziningi ezisebenzayo ezifaka: i-Pioglitazone HCl, i-Aminophylline, i-Berberine HCl, i-Milnacipran HCl, i-Cefixime, i-Nicorandil, nezinye eziningi

5. Izakhiwo Eziphakeme Zomzimba

Ukucindezelwa okuhle kakhulu kanye nokuqina kwethebhulethi
Igcina ubuqotho bethebhulethi ngenkathi iqinisekisa ukuqhekeka okusheshayo
Izakhiwo ezinhle zokugeleza kokucindezela okuqondile
Izinzile naphezu kokungabi nalutho - gcina ezitsheni ezivalwe kahle

6. Iphrofayili Yokulawula Nekhwalithi

Ihlangabezana nezindinganiso ze-pharmacopoeia ze-USP-NF, EP, JP, kanye ne-ChP
I-CDE ebhalisiwe (F20230000328) yemakethe yaseShayina
I-GMP ekhiqizwe ngokulawulwa kwekhwalithi okuqinile
Kutholakala ngokusekelwa okusemthethweni kokufakwa kwamafayela emhlabeni jikelele