Ukuchazwa Kwezimfanelo Zekhwalithi Nokuhlaziywa Kwezici Ezithonyayo ku-HIGH SHEAR MIXER GRANULATION

Ukuchazwa Kwezimfanelo Zekhwalithi Nokuhlaziywa Kwezici Ezithonyayo ku-HIGH SHEAR umxube UKUPHUMA

Ubuchwepheshe be-High Shear Mixer Granulation busetshenziswa kabanzi emkhakheni wemithi eqinile. Lobu buchwepheshe buvame ukuhlanganisa izinto zokusetshenziswa kanye ne-exI-CIPIzakhi ngokulinganayo ukuze zakhe izinhlayiya ezingama-180-2000 μ m, ezisetshenziswa ezinqubweni ezingezansi njengokucindezela ithebhulethi, ukugcwaliswa kwe-capsule, kanye nokufakwa kwezingxenye. Ukuqaliswa kwenqubo yokuhlanganisa okumanzi kubalulekile ekuhlinzekeni izinhlayiya ezisezingeni eliphezulu nezifanelekile ezingezansi. Izakhiwo zezinhlayiya zithinta izimfanelo zekhwalithi ezibalulekile zemikhiqizo, njengezinga lokuncibilika, umehluko wesisindo sethebhulethi (umehluko kuvolumu yokulayisha), njalo njalo. Ngokuvamile, singahlola izinhlayiya ngokusekelwe ezinkombeni ezibonakalayo njengokusatshalaliswa kosayizi wezinhlayiya, ukugoba, okuqukethwe komswakama, kanye nokugeleza. Isivuno sosayizi wezinhlayiya esiqondiwe sibhekisela kumaphesenti ezinhlayiya ezihlangabezana nobubanzi bosayizi wezinhlayiya obulindelwe kumkhiqizo wokugcina kuya kubuningi bezinhlayiya eziphelele, ezingalinganiswa ngokuhlola, i-laser, kanye nezindlela zesithombe. Ngokusho kwendinganiso yemboni i-JB/T 20015, indinganiso yokuhlola ukusebenza kwama-granulators okuxuba okumanzi ukuthi izinga lezinhlayiya zesitashi sommbila, i-dextrin, kanye noshukela impuphu ku-3:2:1 isilinganiso ngemva kokomisa akufanele sibe ngaphansi kuka-75% ngaphakathi kobubanzi obungu-180-2000 μ m. Amabhizinisi aqinisekisa usayizi wezinhlayiya ze-granulation emanzi ngokusekelwe ezidingweni zenqubo ezansi, futhi ububanzi bosayizi wezinhlayiya kanye nesilinganiso sezinhlayiya kuncike ezidingweni ezithile zomkhiqizo. Ukusatshalaliswa kosayizi wezinhlayiya kuchaza isilinganiso sezinhlayiya zobukhulu obuhlukene ohlelweni lwezinhlayiya, kuyilapho izinga lokusabalala lilinganiswa ububanzi bokusatshalaliswa kosayizi wezinhlayiya. Ukusatshalaliswa kosayizi wezinhlayiya kutholakala ngezindlela zezibalo ngokusekelwe emiphumeleni yokutholakala kosayizi wezinhlayiya. Ngisho noma isivuno sosayizi wezinhlayiya eziqondiwe sifana, kungase kube nomehluko omkhulu ekusabalaleni kosayizi wezinhlayiya. Kwemithi eminingi, sikhetha ukusatshalaliswa kosayizi wezinhlayiya ezincane ngaphakathi kobubanzi bokutholakala obulindelekile bosayizi wezinhlayiya eziqondiwe ukuqinisekisa ukuhambisana komphumela wokuncibilika kwezokwelapha. Ububanzi bokusatshalaliswa kosayizi wezinhlayiya I-Span ivame ukusetshenziswa ukukala izinga lokusabalala kokusabalalisa kosayizi wezinhlayiya. Indlela yokubala imi kanje: (1) Kulesi sibalo: D90- ububanzi bezinhlayiya obuhambisana nokubalwa okuhlanganisiwe kosayizi wezinhlayiya kusukela kokuncane kuya kokukhulu okufika ku-90% wesamba, μm； D10- ububanzi bezinhlayiya obuhambisana nokubalwa okuhlanganisiwe kosayizi wezinhlayiya kusukela kokuncane kuya kokukhulu okufika ku-10% wesamba, μm； D50- ububanzi bezinhlayiya obuhambisana nokubalwa okuhlanganisiwe kosayizi wezinhlayiya kusukela kokuncane kuya kokukhulu okufika ku-50% wesamba, μm。 Uma isikhala sikhulu, umehluko omkhulu ngobukhulu bezinhlayiya futhi ubumpofu buyanda; Ngokuphambene nalokho, kufana kakhulu. Isithombe 1 sibonisa umehluko ebubanzini bokusatshalaliswa kosayizi wezinhlayiya zezinhlayiya ezilungiselelwe kusetshenziswa izinto zokusetshenziswa ezifanayo kanye nemingcele yenqubo ehlukene. Kungabonakala ukuthi nakuba isivuno sosayizi wezinhlayiya eziqondiwe esingu-180-2000 μ m sifana, umehluko ebubanzini bokusatshalaliswa kosayizi wezinhlayiya ubalulekile (ijika eliluhlaza okwesibhakabhaka linenani elincane le-Span, ijika eliphuzi linenani eliphakathi le-Span, kanti ijika eliwolintshi linenani elikhulu le-Span). Ngakho-ke, ukukhetha inani le-Span elifanele ngokusekelwe ezidingweni zenqubo kuyinto ebalulekile ekuhloleni ukusebenza kahle kwe-wet granulation.